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ProductName:Y-Chromosome Microdeletions Gene Detection Kit

Y-Chromosome Microdeletions Gene Detection Kit

 

WHO statistics, 15% of couples around the world suffering from infertility caused by the man, more than 50%, of which more than 30% of male infertility is caused due to genetic factors spermatogenic failure caused. The incidence of Y chromosome microdeletions in male infertility caused by spermatogenesis after the Klinefelter syndrome, living in the the second genetic factors. Any site microdeletions may lead to a fine obstacles lead to infertility, caused by the lack of multiple sites, usually due to azoospermia factor gene family (Azooapermia factor, AZF) on the Y chromosome q11.

Application:

1. In vitro fertilization(IVF)assisted fertility, particularly the detection of intracytoplasmic sperm injection(ICSI)technique before treatment;

2. Oligozoospermia or azoospermia with genetic detection;

3. Sperm bank screening for hospital procreative genetics, procreative medicine center.

 

Features:

1. Quickly and accurately detect the Deletion of Y chromosome, including 15 loci in AZF clusters. Very important for male yeld molecular diagnosis and clinical assisted reproduction treatment.

2. Simultaneous detection of 15 sequence tag sites(STSs), covering all the AZF region;

3. High specific primer and unique amplification system ensure the multiplex PCR uniformity;

4. Unique design of antipollution, effectively avoid the generation of false-positive;

5. Exceed the detect standards of European Academy of Andrology (EAA) and European Molecular Genetics Quality Network (EMQN), increase the specific STS in detection of the Chinese population.

Technique Features:

Detection of Y chromosome microdeletion with multiple PCR method can be applied to test Including 15 sequence tag sites (STSs) in AZFa, AZFb, AZFc and AZFd four Areas, Results of the PCR products should be read with electrophoresis method. Judge the results by the existence or not of internal control and 15 STSs.